Utilizad este identificador para citar o enlazar este documento: http://hdl.handle.net/2072/304796

Exposure to Endocrine-Disrupting Chemicals (EDCs) during pregnancy and blood pressure
Seminatti, Chiara
Exposure to endocrine-disrupting chemicals (EDCs) has been largely studied in the last years and it has been related to different negative effects on human health. Among them alteration of fetal growth, deficiencies of neuronal development in children born from chronically exposed mothers, alterations of the male and female sexual apparatus have been described. Only few studies have investigated the association between exposure during pregnancy and change in blood pressure in pregnant women, although cardiovascular diseases (CVDs) are one of the most public health concern. In this study we have investigated the association between several EDCs biomarkers belonging to phthalates (10 metabolites), phenols (7 metabolites) and organophosphate pesticides (6 metabolites), and alterations of blood pressure (BP) in pregnant women. Women included in the study were 153 and were volunteer participant in Human Early-Life Exposome (HELIX) project. Association with urine concentration and blood pressure was investigated using a multivariates exposure model to assess the association between each compound and BP in studied women. Significant negative association was observed between systolic BP and exposure to MEP and MiBP (Phthalates) and to DEP and DETP (Organophosphate Pesticides) and between diastolic BP and exposure to MBzP (phthalates) and TRCS (phenol) during pregnancy. Our results are inconsistent with previous study that investigated similar associations and require replication.
61 - Medicina
Salut humana
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36 p.

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