Title:
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The effectiveness of influenza vaccination in the elderly in Spain in two influenza seasons: a multicenter case-control study
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Author:
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Domínguez García, Àngela; Soldevila, Núria; Toledo, Diana; Godoy, Pere; Espejo, Elena; Fernández, M.A.; Mayoral, J.M.; Castilla, Jesús; Egurrola, Mikel; Tamames, Sonia; Astray, Jenaro; Morales-Suárez-Varela, M.; Torner Gràcia, Núria
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Other authors:
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Universitat de Barcelona |
Abstract:
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Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals. |
Subject(s):
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-Grip -Vacunació -Persones grans -Espanya -Influenza -Vaccination -Older people -Spain |
Rights:
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cc-by (c) Domínguez García, Àngela et al., 2017
http://creativecommons.org/licenses/by/3.0/es |
Document type:
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Article Article - Published version |
Published by:
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European Centre for Disease Prevention and Control (ECDC)
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