To access the full text documents, please follow this link: http://hdl.handle.net/2445/114213

Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
Royo, Felix; Zúñiga García, Patricia; Torrano, Verónica; Loizaga-Iriarte, Ana; Sanchez-Mosquera, Pilar; Ugalde-Olano, Aitziber; González, Esperanza; Cortazar, Ana Rosa; Palomo, Laura; Fernández-Ruiz, Sonia; Lacasa-Viscasillas, Isabel; Berdasco, María; Sutherland, James David; Barrio, Rosa; Zabala Letona, Amaia; Martín-Martín, Natalia; Arruabarrena-Aristorena, Amaia; Valcarcel-Jimenez, Lorea; Caro Maldonado, Alfredo; Gonzalez-Tampan, Jorge; Cachi-Fuentes, Guido; Esteller, Manel; Aransay, Ana Maria; Unda Urzaiz, Miguel; Falcón-Pérez, Juan M.; Carracedo, Arkaitz
Extracellular vesicles (EV) are emerging structures with promising properties for intercellular communication. In addition, the characterization of EV in biofluids is an attractive source of non-invasive diagnostic, prognostic and predictive biomarkers. Here we show that urinary EV (uEV) from prostate cancer (PCa) patients exhibit genuine and differential physical and biological properties compared to benign prostate hyperplasia (BPH). Importantly, transcriptomics characterization of uEVs led us to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients. Tissue and cell line analysis strongly suggested that the status of CDH3 in uEVs is a distal reflection of changes in the expression of this cadherin in the prostate tumor. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. Our results reveal that uEVs could represent a non-invasive tool to inform about the molecular alterations in PCa.
Càncer de pròstata
Malalties de la pròstata
Marcadors tumorals
Marcadors bioquímics
Anàlisi d'orina
Prostate cancer
Prostatic diseases
Tumor markers
Biochemical markers
Urine analysis
cc-by (c) Royo, Felix et al., 2016
http://creativecommons.org/licenses/by/3.0/es
Article
info:eu-repo/semantics/publishedVersion
Impact Journals
         

Show full item record

Related documents

Other documents of the same author

Royo, Felix; Zúñiga García, Patricia; Torrano, Verónica; Loizaga-Iriarte, Ana; Sanchez-Mosquera, Pilar; Ugalde-Olano, Aitziber; González, Esperanza; Cortazar, Ana Rosa; Palomo, Laura; Fernández-Ruiz, Sonia; Lacasa-Viscasillas, Isabel; Berdasco, María; Sutherland, James David; Barrio, Rosa; Zabala Letona, Amaia; Martín-Martín, Natalia; Arruabarrena-Aristorena, Amaia; Valcarcel-Jimenez, Lorea; Caro Maldonado, Alfredo; Gonzalez-Tampan, Jorge; Cachi-Fuentes, Guido; Esteller, Manel; Aransay, Ana Maria; Unda Urzaiz, Miguel; Falcón-Pérez, Juan M.; Carracedo, Arkaitz
Torrano, Verónica; Valcarcel-Jimenez, Lorea; Cortazar, Ana Rosa; Liu, Xiaojing; Urosevic, Jelena; Castillo Martin, Mireia; Fernández Ruiz, Sonia; Morciano, Giampaolo; Caro Maldonado, Alfredo; Guiu, Marc; Zúñiga García, Patricia; Graupera, Mariona; Bellmunt, Anna; Pandya, Pahini; Lorente, Mar; Martín Martín, Natalia; Sutherland, James David; Sanchez-Mosquera, Pilar; Bozal Basterra, Laura; Zabala Letona, Amaia; Arruabarrena Aristorena, Amaia; Berenguer, Antonio; Embade, Nieves; Ugalde Olano, Aitziber; Lacasa-Viscasillas, Isabel; Loizaga Iriarte, Ana; Unda Urzaiz, Miguel; Schultz, Nikolaus; Aransay, Ana Maria; Sanz Moreno, Victoria; Barrio, Rosa; Velasco, Guillermo; Pinton, Paolo; Cordon Cardo, Carlos; Locasale, Jason W.; Gomis i Cabré, Roger; Carracedo, Arkaitz
Martín-Martín, Natalia; Piva, Marco; Urosevic, Jelena; Aldaz, Paula; Sutherland, James David; Fernández-Ruiz, Sonia; Arreal, Leire; Torrano, Verónica; Cortazar, Ana Rosa; Planet, Evarist; Guiu, Marc; Radosevic Robin, Nina; Garcia, Stephane; Macías, Iratxe; Salvador, Fernando; Domenici, Giacomo; Rueda, Oscar M.; Zabala Letona, Amaia; Arruabarrena-Aristorena, Amaia; Zúñiga García, Patricia; Caro Maldonado, Alfredo; Valcarcel-Jimenez, Lorea; Sánchez Mosquera, Pilar; Varela Rey, Marta; Martínez Chantar, Maria Luz; Anguita, Juan; Ibrahim, Yasir H.; Scaltriti, Maurizio; Lawrie, Charles H.; Aransay, Ana Maria; Iovanna, Juan L.; Baselga, Jose; Caldas, Carlos; Barrio, Rosa; Serra, Violeta; Vivanco, Maria d. M.; Matheu, Ander; Gomis i Cabré, Roger; Carracedo, Arkaitz
Serra, Helena; Chivite, Íñigo; Angulo Aguado, Ana; Soler, Adriana; Sutherland, James David; Arruabarrena-Aristorena, Amaia; Ragab, Anan; Lim, Radiance; Malumbres, Marcos; Fruttiger, Marcus; Potente, Michael; Serrano, Manuel; Fabra Fres, Àngels; Viñals Canals, Francesc; Casanovas i Casanovas, Oriol; Pandolfi, Pier Paolo; Bigas Salvans, Anna; Carracedo, Arkaitz; Gerhardt, Holger; Graupera, Mariona
Serra, Helena; Chivite, Íñigo; Angulo Aguado, Ana; Soler, Adriana; Sutherland, James David; Arruabarrena-Aristorena, Amaia; Ragab, Anan; Lim, Radiance; Malumbres, Marcos; Fruttiger, Marcus; Potente, Michael; Serrano, Manuel; Fabra Fres, Àngels; Viñals Canals, Francesc; Casanovas i Casanovas, Oriol; Pandolfi, Pier Paolo; Bigas Salvans, Anna; Carracedo, Arkaitz; Gerhardt, Holger; Graupera, Mariona
 

Coordination

 

Supporters