Graphene electrodes are promising candidates to improvereproducibility and stability in molecular electronics through new electrode−molecule anchoring strategies. Here we report sequentialelectron transport in few-layer graphene transistors containing individualcurcuminoid-based molecules anchored to the electrodes via π −π orbital bonding. We show the coexistence of inelastic co-tunneling excitations with single-electron transport physics due to an intermediate molecule−electrode coupling; we argue that an intermediate electron−phononcoupling is the origin of these vibrational-assisted excitations. Theseexperimental observations are complemented with density functionaltheory calculations to model electron transport and the interaction between electrons and vibrational modes of thecurcuminoid molecule. We find that the calculated vibrational modes of the molecule are in agreement with theexperimentally observed excitations