Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/113435

Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
Fernández de Larrea, Nerea; Michel, Angelika; Romero, Beatriz; Pérez Gómez, Beatriz; Moreno Aguado, Víctor; Martín, Vicente; Dierssen-Sotos, Trinidad; Jiménez Moleón, José J.; Castilla, Jesús; Tardón, Adonina; Ruiz, Irune; Peiró, Rosana; Tejada, Antonio; Chirlaque, María Dolores; Butt, Julia A.; Olmedo Requena, Rocío; Gómez Acebo, Inés; Linares, Pedro; Boldo, Elena; Castells Garangou, Antoni; Pawlita, Michael; Castaño Vinyals, Gemma; Kogevinas, Manolis; Sanjosé Llongueras, Silvia de; Pollán, Marina; Campo, Rosa del; Waterboer, Tim; Aragonés, Nuria
Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >/=4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results:H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagdelta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.
Helicobacter pylori
Càncer colorectal
Helicobacter pylori
Colorectal cancer
cc by (c) Fernández de Larrea et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
Artículo
info:eu-repo/semantics/publishedVersion
Frontiers Research Foundation
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Huerta, José M.; Chirlaque, María Dolores; Molina, Antonio José; Amiano, Pilar; Martín, Vicente; Fernández Villa, Tania; Pérez Gómez, Beatriz; Moreno Aguado, Víctor; Burgui, Rosana; Gómez Acebo, Inés; Ramos Lora, Manuel; Fernández Tardón, Guillermo; Peiró, Rosana; Olmedo Requena, Rocío; Pollán, Marina; Kogevinas, Manoli; Castaño Vinyals, Gemma; Aragonés, Nuria
Villanueva, Cristina M.; Gracia-Lavedan, Esther; Bosetti, Cristina; Righi, Elena; Molina, Antonio José; Martín, Vicente; Boldo, Elena; Aragonés, Nuria; Pérez Gómez, Beatriz; Pollán, Marina; Gómez Acebo, Inés; Altzibar, Jone M.; Jiménez Zabala, Ana; Ardanaz, Eva; Peiró, Rosana; Tardón, Adonina; Chirlaque, María Dolores; Tavani, Alessandra; Polesel, Jerri; Serraino, Diego; Pisa, Federica E.; Castaño-Vinyals, Gemma; Espinosa, Anna; Espejo-Herrera, Nadia; Palau, Margarita; Moreno Aguado, Víctor; Vecchia, Carlo La; Aggazzotti, Gabriella; Nieuwenhuijsen, Mark J.; Kogevinas, Manolis
Castaño-Vinyals, Gemma; Aragonés, Nuria; Pérez-Gómez, Beatriz; Martín, Vicente; Llorca Díaz, Javier; Moreno Aguado, Víctor; Altzibar, Jone M.; Ardanaz, Eva; Sanjosé Llongueras, Silvia de; Jiménez Moleón, José J.; Tardón, Adonina; Alguacil, Juan; Peiró, Rosana; Marcos-Gragera, Rafael; Navarro Sánchez, Carmen; Pollán, Marina; Kogevinas, Manolis
Ibánez Sanz, Gemma; Díez Villanueva, Anna; Henar Alonso, M.; Rodríguez Moranta, Francisco; Pérez Gómez, Beatriz; Bustamante Pineda, Mariona; Martin, Vicente; Llorca Díaz, Javier; Amiano, Pilar; Ardanaz, Eva; Tardón, Adonina; Jiménez Moleón, José J.; Peiró, Rosana; Alguacil, Juan; Navarro, Carmen; Guinó, Elisabet; Binefa, Gemma; Fernández Navarro, Pablo; Espinosa, Anna; Dávila Batista, Verónica; Molina, Antonio José; Palazuelos, Camilo; Castaño-Vinyals, Gemma; Aragonés, Nuria; Kogevinas, Manolis; Pollán, Marina; Moreno, Victor
Lope, Virginia; Fernández de Larrea, Nerea; Pérez-Gómez, Beatriz; Martín, Vicente; Moreno, Victor; Costas, Laura; Longo, Federico; Jiménez-Moleón, José Juan; Llorca Díaz, Javier; Ascunce, Nieves; Peiró, Rosana; Altzibar, Jone M.; Tardón, Adonina; Alguacil, Juan; Navarro, Carmen; Sierra, Ángeles; Vega, Ana Belén; Villafañe, Amaya; Castaño-Vinyals, Gemma; Kogevinas, Manolis; Pollán, Marina; Aragonés, Nuria
 

Coordinación

 

Patrocinio