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Título:	Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors
Autor/a:	Juliachs Milà, Mercè; Vidal-Bel, August; García del Muro Solans, Xavier; Piulats, Josep M.; Condom i Mundó, Enric; Casanovas i Casanovas, Oriol; Graupera i Garcia-Milà, Mariona; Germà Lluch, José Ramón; Villanueva Garatachea, Alberto; Viñals Canals, Francesc
Abstract:	Background: Cisplatin (CDDP) resistance in testicular germ cell tumors (GCTs) is still a clinical challenge, and one associated with poor prognosis. The purpose of this work was to test pazopanib, an anti-tumoral and anti-angiogenic multikinase inhibitor, and its combination with lapatinib (an anti-ErbB inhibitor) in mouse orthotopic models of human testicular GCTs. Methods: We used two different models of human testicular GCTs orthotopically grown in nude mice; a CDDP-sensitive choriocarcinoma (TGT38) and a new orthotopic model generated from a metastatic GCT refractory to first-line CDDP chemotherapy (TGT44). Nude mice implanted with these orthotopic tumors were treated with the inhibitors and the effect on tumoral growth and angiogenesis was evaluated. Results: TGT44 refractory tumor had an immunohistochemical profile similar to the original metastasis, with characteristics of yolk sac tumor. TGT44 did not respond when treated with cisplatin. In contrast, pazopanib had an anti-angiogenic effect and anti-tumor efficacy in this model. Pazopanib in combination with lapatinib in TGT38, an orthotopic model of choriocarcinoma had an additive effect blocking tumor growth. Conclusions: We present pazopanib as a possible agent for the alternative treatment of CDDP-sensitive and CDDP-refractory GCT patients, alone or in combination with anti-ErbB therapies.
Materia(s):	-Càncer -Malalties del testicle -Tumors -Cisplatí -Cancer -Testis diseases -Tumors -Cisplatin
Derechos:	cc-by (c) Juliachs Milà, Mercè et al., 2013 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	BioMed Central
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