Título:
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Access to enantiopure 4-substituted 1,5-aminoalcohols from phenylglycinol-derived δ-lactams: synthesis of Haliclona alkaloiods
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Autor/a:
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Amat Tusón, Mercedes; Guignard, Guillaume; Llor Brunés, Núria; Bosch Cartes, Joan
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Otros autores:
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Universitat de Barcelona |
Abstract:
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LiNH2BH3-promoted reductive opening of 8-substituted phenylglycinol-derived oxazolopiperidone lactams leads to enantiopure 4-substituted-5-aminopentanols, which are used as starting building blocks in the synthesis of the Haliclona alkaloids haliclorensin C, haliclorensin, and halitulin (formal). The starting lactams are easily accessible by a cyclocondensation reaction of (R)-phenylglycinol with racemic γ-subtituted δ-oxoesters, in a process that involves a dynamic kinetic resolution. |
Materia(s):
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-Síntesi orgànica -Alcaloides -Lactames -Compostos heterocíclics -Organic synthesis -Alkaloids -Lactams -Heterocyclic compounds |
Derechos:
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(c) American Chemical Society , 2014
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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American Chemical Society
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Compartir:
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