Título:
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Defining the next generation of Plasmodium vivax diagnostic
tests for control and elimination: Target product profiles
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Autor/a:
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Ding, Xavier C.; Ade, Maria Paz; Baird, J. Kevin; Cheng, Qin; Cunningham, Jane; Dhorda, Mehul; Drakeley, Chris; Felger, Ingrid; Gamboa, Dionicia; Harbers, Matthias; Herrera, Sócrates; Lucchi, Naomi; Mayor Aparicio, Alfredo Gabriel; Mueller, Ivo; Sattabongkot, Jetsumon; Ratsimbason, Arsène; Richards, Jack; Tanner, Marcel; Gonzalez, Iveth J.
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Abstract:
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The global prevalence of malaria has decreased over the past
fifteen years, but similar gains have not been realized against
Plasmodium vivax because this species is less responsive to
conventional malaria control interventions aimed principally at
P. falciparum. Approximately half of all malaria cases outside
of Africa are caused by P. vivax. This species places dormant
forms in human liver that cause repeated clinical attacks
without involving another mosquito bite. The diagnosis of acute
patent P. vivax malaria relies primarily on light microscopy.
Specific rapid diagnostic tests exist but typically perform
relatively poorly compared to those for P. falciparum. Better
diagnostic tests are needed for P. vivax. To guide their
development, FIND, in collaboration with P. vivax experts,
identified the specific diagnostic needs associated with this
species and defined a series of three distinct target product
profiles, each aimed at a particular diagnostic application: (i)
point-of-care of acutely ill patients for clinical care
purposes; (ii) point-of-care asymptomatic and otherwise
sub-patent residents for public health purposes, e.g., mass
screen and treat campaigns; and (iii) ultra-sensitive not
point-of-care diagnosis for epidemiological
research/surveillance purposes. This report presents and
discusses the rationale for these P. vivax-specific diagnostic
target product profiles. These contribute to the rational
development of fit-for-purpose diagnostic tests suitable for the
clinical management, control and elimination of P. vivax
malaria. |
Materia(s):
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-Plasmodium vivax -Malalties parasitàries -Plasmodium vivax -Parasitic diseases |
Derechos:
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cc0 (c) Ding et al., 2017
http://creativecommons.org/publicdomain/zero/1.0/ |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Public Library of Science (PLoS)
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