In this paper, we present estimates of the Human Development Index and the Gender-Related Development Index in the Autonomous Communities of Spain. Our case study of Spain, a developed country with clear gender and regional differences, demonstrates the importance of adjusting human development indices in accordance with gender discrimination and regional inequalities. We also show the significance of the income component in assessing the development level of women in countries like Spain, where lack of employment or low remuneration are the chief characteristics of women's inequality. Our analysis makes clear that the Gender-Related Human Development Index has limited applicability in developed countries; it also illustrates the need for alternative variables or models to assess inequality in those countries.