Title:
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Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens.
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Author:
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Delgado, Julio (Delgado González); Bielig, Torsten; Bonet, Lizette; Carnero-Montoro, Elena; Puente, Xose S.; Colomer Pujol, Dolors; Bosch, Elena; Campo Güerri, Elias; Lozano Soto, Francisco
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Other authors:
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Universitat de Barcelona |
Abstract:
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Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), and surface CD38 or intracytoplasmic ZAP-70 expression. Given that key signalling components of the B-cell receptor (BCR) are relevant contributors to the variable clinical behaviour of CLL (Stevenson et al, 2011) we explored the influence of functionally relevant germline CD5 variants on CLL prognosis. |
Subject(s):
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-Leucèmia limfocítica crònica -Receptors cel·lulars -Cèl·lules B -Biologia molecular -Immunologia -Chronic lymphocytic leukemia -Cell receptors -B cells -Molecular biology -Immunology |
Rights:
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(c) John Wiley & Sons Ltd, 2016
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Document type:
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Article Article - Submitted version |
Published by:
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Blackwell Science
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