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| dc.contributor.author | Martín-Martín, Natalia |
|---|---|
| dc.contributor.author | Piva, Marco |
| dc.contributor.author | Urosevic, Jelena |
| dc.contributor.author | Aldaz, Paula |
| dc.contributor.author | Sutherland, James David |
| dc.contributor.author | Fernández-Ruiz, Sonia |
| dc.contributor.author | Arreal, Leire |
| dc.contributor.author | Torrano, Verónica |
| dc.contributor.author | Cortazar, Ana Rosa |
| dc.contributor.author | Planet, Evarist |
| dc.contributor.author | Guiu, Marc |
| dc.contributor.author | Radosevic Robin, Nina |
| dc.contributor.author | Garcia, Stephane |
| dc.contributor.author | Macías, Iratxe |
| dc.contributor.author | Salvador, Fernando |
| dc.contributor.author | Domenici, Giacomo |
| dc.contributor.author | Rueda, Oscar M. |
| dc.contributor.author | Zabala Letona, Amaia |
| dc.contributor.author | Arruabarrena-Aristorena, Amaia |
| dc.contributor.author | Zúñiga García, Patricia |
| dc.contributor.author | Caro Maldonado, Alfredo |
| dc.contributor.author | Valcarcel-Jimenez, Lorea |
| dc.contributor.author | Sánchez Mosquera, Pilar |
| dc.contributor.author | Varela Rey, Marta |
| dc.contributor.author | Martínez Chantar, Maria Luz |
| dc.contributor.author | Anguita, Juan |
| dc.contributor.author | Ibrahim, Yasir H. |
| dc.contributor.author | Scaltriti, Maurizio |
| dc.contributor.author | Lawrie, Charles H. |
| dc.contributor.author | Aransay, Ana Maria |
| dc.contributor.author | Iovanna, Juan L. |
| dc.contributor.author | Baselga Torres, Josep, 1959- |
| dc.contributor.author | Caldas, Carlos |
| dc.contributor.author | Barrio, Rosa |
| dc.contributor.author | Serra, Violeta |
| dc.contributor.author | Vivanco, Maria d. M. |
| dc.contributor.author | Matheu, Ander |
| dc.contributor.author | Gomis i Cabré, Roger |
| dc.contributor.author | Carracedo, Arkaitz |
| dc.date | 2017-01-16T10:51:24Z |
| dc.date | 2017-01-16T10:51:24Z |
| dc.date | 2016-08-24 |
| dc.date | 2017-01-05T09:14:49Z |
| dc.identifier.citation | 2041-1723 |
| dc.identifier.uri | http://hdl.handle.net/2445/105635 |
| dc.description.abstract | Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggressive breast cancer. The acquisition of aggressiveness and metastatic features in breast tumours is accompanied by the elevated PML expression and enhanced sensitivity to its inhibition. Interestingly, we find that STAT3 is responsible, at least in part, for the transcriptional upregulation of PML in breast cancer. Moreover, PML targeting hampers breast cancer initiation and metastatic seeding. Mechanistically, this biological activity relies on the regulation of the stem cell gene SOX9 through interaction of PML with its promoter region. Altogether, we identify a novel pathway sustaining breast cancer aggressiveness that can be therapeutically exploited in combination with PML-based stratification. |
| dc.format | 13 p. |
| dc.format | application/pdf |
| dc.language.iso | eng |
| dc.publisher | Macmillan |
| dc.relation | Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms12595 |
| dc.relation | Nature Communications, 2016, vol. 7, p. 12595 |
| dc.relation | http://dx.doi.org/10.1038/ncomms12595 |
| dc.rights | cc by (c) Martín et al., 2016 |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es/ |
| dc.subject | Càncer de mama |
| dc.subject | Interacció cel·lular |
| dc.subject | Breast cancer |
| dc.subject | Cell interaction |
| dc.title | Stratification and therapeutic potential of PML in metastatic breast cancer |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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