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| dc.contributor.author | Recasens Alvarez, Carles |
|---|---|
| dc.contributor.author | Ferreira, Ana |
| dc.contributor.author | Milán, Marco |
| dc.date | 2017-01-16T12:10:00Z |
| dc.date | 2017-01-16T12:10:00Z |
| dc.date | 2017-01-03 |
| dc.date | 2017-01-16T12:07:59Z |
| dc.identifier.citation | 2041-1723 |
| dc.identifier.citation | http://dx.doi.org/10.1038/ncomms13815 |
| dc.identifier.uri | http://hdl.handle.net/2445/105644 |
| dc.description.abstract | A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ. |
| dc.format | 14 p. |
| dc.format | application/pdf |
| dc.language.iso | eng |
| dc.publisher | Macmillan |
| dc.relation | Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms13815 |
| dc.relation | Nature Communications, 2017, vol. 8, p. 13815 |
| dc.rights | cc by (c) Recasens et al., 2017 |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es/ |
| dc.subject | Morfogènesi |
| dc.subject | Drosòfila |
| dc.subject | Morphogenesis |
| dc.subject | Drosophila |
| dc.title | JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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