Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/102347

What Makes a Protein Sequence a Prion?
Sabaté Lagunas, Raimon; Rousseau, Frederic; Schymkowitz, Joost; Ventura, Salvador
Universitat de Barcelona
Typical amyloid diseases such as Alzheimer's and Parkinson's were thought to exclusively result from de novo aggregation, but recently it was shown that amyloids formed in one cell can cross-seed aggregation in other cells, following a prion-like mechanism. Despite the large experimental effort devoted to understanding the phenomenon of prion transmissibility, it is still poorly understood how this property is encoded in the primary sequence. In many cases, prion structural conversion is driven by the presence of relatively large glutamine/asparagine (Q/N) enriched segments. Several studies suggest that it is the amino acid composition of these regions rather than their specific sequence that accounts for their priogenicity. However, our analysis indicates that it is instead the presence and potency of specific short amyloid-prone sequences that occur within intrinsically disordered Q/N-rich regions that determine their prion behaviour, modulated by the structural and compositional context. This provides a basis for the accurate identification and evaluation of prion candidate sequences in proteomes in the context of a unified framework for amyloid formation and prion propagation.
Prions
Malalties per prions
Llevats
Seqüència d'aminoàcids
Nucleació
Prions
Prion diseases
Yeast
Amino acid sequence
Nucleation
cc-by (c) Sabaté Lagunas, Raimon et al., 2015
http://creativecommons.org/licenses/by/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
Public Library of Science (PLoS)
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Pouplana, Sergi; Espargaró Colomé, Alba; Galdeano Cantador, Carlos; Viayna, Elisabet; Sola, Irene; Ventura, Salvador; Muñoz-Torrero López-Ibarra, Diego; Sabaté Lagunas, Raimon
Pouplana, Sergi; Espargaró Colomé, Alba; Galdeano Cantador, Carlos; Viayna, Elisabet; Sola, Irene; Ventura, Salvador; Muñoz-Torrero López-Ibarra, Diego; Sabaté Lagunas, Raimon
Viayna, E.; Sola, I.; Bartolini, Manuela; De Simone, A.; Tapia-Rojas, C.; Serrano, Felipe G.; Sabaté Lagunas, Raimon; Juárez-Jiménez, Jordi; Pérez Fernández, Belén; Luque Garriga, F. Xavier; Andrisano, Vincenza; Clos Guillén, M. Victòria; Inestrosa, Nibaldo C.; Muñoz-Torrero López-Ibarra, Diego
Sabaté Lagunas, Raimon; Raventós Olivella, Judit