Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/101708

Magnetite-Amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer's disease
Teller, Sara; Tahirbegi, Islam Bogachan; Mir Llorente, Mònica; Samitier i Martí, Josep; Soriano i Fradera, Jordi
Universitat de Barcelona
The understanding of the key mechanisms behind human brain deterioration in Alzheimer' disease (AD) is a highly active field of research. The most widespread hypothesis considers a cascade of events initiated by amyloid-β peptide fibrils that ultimately lead to the formation of the lethal amyloid plaques. Recent studies have shown that other agents, in particular magnetite, can also play a pivotal role. To shed light on the action of magnetite and amyloid-β in the deterioration of neuronal circuits, we investigated their capacity to alter spontaneous activity patterns in cultured neuronal networks. Using a versatile experimental platform that allows the parallel monitoring of several cultures, the activity in controls was compared with the one in cultures dosed with magnetite, amyloid-β and magnetite-amyloid-β complex. A prominent degradation in spontaneous activity was observed solely when amyloid-β and magnetite acted together. Our work suggests that magnetite nanoparticles have a more prominent role in AD than previously thought, and may bring new insights in the understanding of the damaging action of magnetite-amyloid-β complex. Our experimental system also offers new interesting perspectives to explore key biochemical players in neurological disorders through a controlled, model system manner.
Malaltia d'Alzheimer
Magnetita
Amiloïdosi
Alzheimer's disease
Magnetite
Amyloidosis
cc-by-nc-nd (c) Teller, Sara et al., 2015
http://creativecommons.org/licenses/by-nc-nd/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
Nature Publishing Group
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Tahirbegi, Islam Bogachan; Alvira, M.; Mir Llorente, Mònica; Samitier i Martí, Josep
Mir Llorente, Mònica; Lugo, Roberto; Tahirbegi, Islam Bogachan; Samitier i Martí, Josep
Tahirbegi, Islam Bogachan; Alvira, M.; Mir Llorente, Mònica; Samitier i Martí, Josep
Mir Llorente, Mònica; Lugo, Roberto; Tahirbegi, Islam Bogachan; Samitier i Martí, Josep
Teller, Sara; Granell, Clara; Domenico, M. de; Soriano i Fradera, Jordi; Gómez, S.; Arenas, Àlex
 

Coordinación

 

Patrocinio