Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/101485

Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study
Mandal, J.; Malla, B.; Steffensen, R.; Costa, L.; Egli, A.; Trendelenburg, M.; Blasi, Francesco; Kostikas, K.; Welte, T.; Torres Martí, Antoni; Louis, R.; Boersma, W.; Milenkovic, B.; Aerts, J.; Rohde, G. G.; Lacoma, A.; Rentsch, K.; Roth, M.; Tamm, M.; Stolz, D.
Universitat de Barcelona
Background: Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and circulating MBL protein levels are associated with clinically relevant outcomes in the Predicting Outcome using systemic Markers In Severe Exacerbations of COPD PROMISE-COPD cohort. Methods: We followed 277 patients with stable COPD GOLD stage II-IV COPD over a median period of 733 days (IQR 641-767) taking survival as the primary outcome parameter. Patients were dichotomized as frequent (≥2 AECOPD/year) or infrequent exacerbators. Serum MBL levels and single nucleotide polymorphisms of the MBL2 gene were assessed at baseline. Results: The MBL2-HYPD haplotype was significantly more prevalent in frequent exacerbators (OR: 3.33; 95 % CI, 1.24-7.14, p = 0.01). The median serum MBL concentration was similar in frequent (607 ng/ml, [IQR; 363.0-896.0 ng/ml]) and infrequent exacerbators (615 ng/ml, [IQR; 371.0-942.0 ng/ml]). Serum MBL was not associated with lung function characteristics or bacterial colonization in sputum. However, high serum MBL at stable state was associated with better survival compared to low MBL (p = 0.046, log rank test). Conclusions: In COPD, the HYPD haplotype of MBL2 gene is associated with frequent exacerbations and high serum MBL is linked to increased survival.
ADN mitocondrial
Gens
Malalties dels pulmons
Mitochondrial DNA
Genes
Pulmonary diseases
cc-by (c) Mandal, J. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
BioMed Central
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Blasi, Francesco; Garau, J. (Javier); Medina, Jesús; Avila, Marco; McBRide, Kyle; Ostermann, Helmut; Carratalà, Jordi
Lázaro Villa, José Antonio; Polo Querol, Víctor; Costa, L.; Teixeira, A.
Chanclou, Philippe; Schrenk, Bernhard; Lázaro Villa, José Antonio; Klonidis, Dimitrios; Bonada Bo, Francesc; Saliou, Fabienne; Polo Querol, Víctor; López Pastor, Eduardo Tommy; Le, Q.T.; Brenot, Romain; de Valicourt, Guilhem; Spirou, S.; Soila, Risto; Leino, D.; Tosi Beleffi, Giorgio M.; Tomkos, Ioannis; Chatzi, Sotiria; Teixeira, A.; Costa, L.; Kazmierski, Christophe; Prats, Jordi
Prat Gomà, Josep Joan; Polo Querol, Víctor; Lázaro Villa, José Antonio; Bonada, F.; López Pastor, Eduardo Tommy; Schrenk, Bernhard; Omella, M.; Saliou, F.; Le, Q.T.; Chanclou, P.; Leino, D.; Soila, R.; Spirou, S.; Costa, L.; Teixeira, A.; Tosi-Beleffi, G.M.; Klonidis, Dimitrios; Tomkos, Ioannis