Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/100268

Effects of anosognosia and neuropsychiatric symptoms on the quality of life of patients with alzheimer's disease: a 24-month follow-up study
Conde Sala, Josep Lluís; Turró Garriga, O.; Piñan Hernández, S.; Portellano Ortiz, C.; Viñas Diez, V.; Gascón Bayarri, J.; Reñé Ramírez, R.
Universitat de Barcelona
Objectives: Neuropsychiatric symptoms and anosognosia are known to influence the perceived quality of life of patients (QoL-p) with Alzheimer's disease (AD). This study analysed their impact on patient and caregiver ratings of QoL-p and how these ratings changed in relation to the severity of dementia. Methods: A baseline sample of 221 patients and caregivers was followed up over 24 months. Instruments: Neuropsychiatric Inventory (NPI), Anosognosia Questionnaire-Dementia (AQ-D), Quality of Life-Alzheimer's Disease (QoL-AD), and the Global Deterioration Scale (GDS). Longitudinal data were analysed using generalized linear models. Results: In the multivariate analysis, greater anosognosia was always associated with higher ratings of QoL-p among patients, especially at 24 months (p < 0.001), and with more negative ratings among caregivers, especially at baseline (p < 0.001). A higher total NPI score was associated with a more negative rating of QoL-p among caregivers (p < 0.001), and it also had a smaller negative effect on patients' self-ratings (p = 0.001). The neuropsychiatric symptoms (NPI) associated with a more negative view of QoL-p were depression, for patients' self-ratings, and apathy and agitation for caregiver ratings. The discrepancy between patient and caregiver ratings increased in line with the severity of dementia. Conclusion: Neuropsychiatric symptoms and anosognosia have differential effects on patient and caregiver ratings of the quality of life of patients with Alzheimer's disease. Key words: Alzheimer's disease, quality of life, anosognosia, neuropsychiatric symptoms, caregivers, patients.
Malaltia d'Alzheimer
Qualitat de vida
Neuropsiquiatria
Alzheimer's disease
Quality of life
Neuropsychiatry
(c) John Wiley & Sons, 2015
Artículo
info:eu-repo/semantics/acceptedVersion
John Wiley & Sons
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Turró Garriga, O.; Garre Olmo, J.; Vilalta Franch, J.; Conde Sala, Josep Lluís; de Gracia Blanco., M; López Pousa, S.
Conde Sala, Josep Lluís; Reñé-Ramírez, Ramón; Turró Garriga, Oriol; Gascón-Bayarri, J.; Juncadella i Puig, Montserrat; Moreno-Cordón, L.; Viñas Diez, V.; Garre Olmo, Josep
Conde Sala, Josep Lluís; Reñé Ramírez, Ramon; Turró Garriga, Oriol; Gascón-Bayarri, J.; Juncadella i Puig, Montserrat; Moreno-Cordón, L.; Viñas Diez, V.; Garre Olmo, Josep
Conde Sala, Josep Lluís; Reñé Ramírez, Ramon; Turró Garriga, Oriol; Gascón-Bayarri, J.; Juncadella i Puig, Montserrat; Moreno-Cordón, L.; Viñas Diez, V.; Vilalta Franch, Joan; Garre Olmo, Josep
Conde Sala, Josep Lluís; Reñé-Ramírez, Ramón; Turró Garriga, Oriol; Gascón-Bayarri, J.; Juncadella i Puig, Montserrat; Moreno-Cordón, L.; Viñas Diez, V.; Garre Olmo, Josep