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The role of Serratia marcescens porins in antibiotic resistance
Ruiz, Neus; Montero Barrientos, Ma. Teresa; Borrell Hernández, Jordi; Viñas, Miquel
Universitat de Barcelona
The outer membrane permeability of Serratia marcescens was studied by comparing porin-deficient mutants with their parental strains. Omp1-deficient strains were selected by moxalactam resistance, whereas mutants lacking the Omp2 porin were obtained by experimental infection with the SMP2 phage, whose primary receptor is the Omp2 porin. The role of porins was demonstrated in quinolone accumulation assays, where semi-quantitative differences in accumulation were observed. Permeability coefficients to cephaloridine of Omp1 mutants were determined and compared with those of the parental strain. The clinical isolates S. marcescens HCPR1 and 866 showed 30- to 200-fold reduced permeability coefficients when Omp1 porin was absent
Resistència als medicaments
Antibiòtics
Medicaments antibacterians
Serratia marcescens
Drug resistance
Antibiotics
Antibacterial agents
Serratia marcescens
(c) Mary Ann Liebert, Inc., 2003
Article
info:eu-repo/semantics/publishedVersion
Mary Ann Liebert, Inc.
         

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