To access the full text documents, please follow this link: http://hdl.handle.net/2445/67190

Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids
Paris, Clément; Brun, Omar; Pedroso Muller, Enrique; Grandas Sagarra, Anna
Universitat de Barcelona
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids, peptides and peptoids, making use of standard solid-phase procedures. Maleimide deprotection takes place upon heating, which can be followed by either Michael-type or Diels-Alder click conjugation reactions. However, the one-pot procedure in which maleimide deprotection and conjugation are simultaneously carried out provides the target conjugate more quickly and, more importantly, in better yield. This procedure is compatible with conjugates involving oligonucleotides, peptides and peptide nucleic acids. A variety of cyclic peptides and oligonucleotides can be obtained from peptide and oligonucleotide precursors incorporating protected maleimides and thiols.
Pèptids
Oligonucleòtids
Àcids nucleics
Peptides
Oligonucleotides
Nucleic acids
cc-by (c) Paris, Clément et al., 2015
http://creativecommons.org/licenses/by/3.0/es
Article
info:eu-repo/semantics/publishedVersion
MDPI
         

Show full item record

Related documents

Other documents of the same author

Brun, Omar; Agramunt, Jordi; Raich, Lluïs; Rovira, Carme; Pedroso Muller, Enrique; Grandas Sagarra, Anna
Elduque Busquets, Xavier; Sánchez, Albert; Sharma, Kapil; Pedroso Muller, Enrique; Grandas Sagarra, Anna
Sánchez, Albert; Pedroso Muller, Enrique; Grandas Sagarra, Anna
Elduque Busquets, Xavier; Pedroso Muller, Enrique; Grandas Sagarra, Anna
 

Coordination

 

Supporters