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Straightforward synthesis of cyclic and bicyclic peptides
Elduque Busquets, Xavier; Pedroso Muller, Enrique; Grandas Sagarra, Anna
Universitat de Barcelona
Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected maleimide moieties and two orthogonally protected cysteines gives access to structurally different bicyclic peptides with isolated or fused cycles.
Aminoàcids
Pèptids
Proteïnes
Amino acids
Peptides
Proteins
(c) American Chemical Society , 2013
Artículo
info:eu-repo/semantics/acceptedVersion
American Chemical Society
         

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