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Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes
Sánchez, Albert; Pedroso Muller, Enrique; Grandas Sagarra, Anna
Universitat de Barcelona
[2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3'-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels-Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate.
Biotecnologia
Àcids nucleics
Espectrometria de masses
Nucleòtids
Compostos heterocíclics
Biotechnology
Nucleic acids
Mass spectrometry
Nucleotides
Heterocyclic compounds
(c) Sánchez, Albert et al., 2012
Article
info:eu-repo/semantics/acceptedVersion
Royal Society of Chemistry
         

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