Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation.

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RECERCAT Home > Universitat de Barcelona > Genètica, Microbiologia i Estadística > Articles publicats en revistes (Genètica, Microbiologia i Estadística) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/61173

dc.contributor	Universitat de Barcelona
dc.contributor.author	Merino Montero, Susana
dc.contributor.author	Wilhelms, Markus
dc.contributor.author	Tomàs Magaña, Juan
dc.date	2015-01-12T15:34:44Z
dc.date	2015-01-12T15:34:44Z
dc.date	2014-10-28
dc.date	2015-01-12T15:34:44Z
dc.identifier.citation	1422-0067
dc.identifier.citation	645555
dc.identifier.uri	http://hdl.handle.net/2445/61173
dc.format	12 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	MDPI
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.3390/ijms151221935
dc.relation	International Journal of Molecular Sciences, 2014, vol. 15, p. 21935-21946
dc.relation	http://dx.doi.org/10.3390/ijms151221935
dc.rights	cc-by (c) Merino Montero, Susana et al., 2014
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Bacteris
dc.subject	Flagel·lats
dc.subject	Regulació genètica
dc.subject	Autoimmunitat
dc.subject	Bacteria
dc.subject	Flagellata
dc.subject	Genetic regulation
dc.subject	Autoimmunity
dc.title	Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation.
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Polar flagellin proteins from Aeromonas hydrophila strain AH-3 (serotype O34) were found to be O-glycosylated with a heterogeneous heptasaccharide glycan. Two mutants with altered (light and strong) polar flagella glycosylation still able to produce flagella were previously obtained, as well as mutants lacking the O34-antigen lipopolysaccharide (LPS) but with unaltered polar flagella glycosylation. We compared these mutants, altogether with the wild type strain, in different studies to conclude that polar flagella glycosylation is extremely important for A. hydrophila adhesion to Hep-2 cells and biofilm formation. Furthermore, the polar flagella glycosylation is an important factor for the immune stimulation of IL-8 production via toll receptor 5 (TLR5).

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