Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/99571
Título:
|
Reaching for the Holy Grail: insights from infection/cure models
on the prospects for vaccines for Trypanosoma cruzi infection
|
Autor/a:
|
Bustamante, Juan Manuel; Tarleton, Rick
|
Abstract:
|
Prevention of Trypanosoma cruzi infection in mammals likely
depends on either prevention of the invading trypomastigotes
from infecting host cells or the rapid recognition and killing
of the newly infected cells by T. cruzi-specific T cells. We
show here that multiple rounds of infection and cure (by drug
therapy) fails to protect mice from reinfection, despite the
generation of potent T cell responses. This disappointing result
is similar to that obtained with many other vaccine protocols
used in attempts to protect animals from T. cruzi infection. We
have previously shown that immune recognition of T. cruzi
infection is significantly delayed both at the systemic level
and at the level of the infected host cell. The systemic delay
appears to be the result of a stealth infection process that
fails to trigger substantial innate recognition mechanisms while
the delay at the cellular level is related to the
immunodominance of highly variable gene family proteins, in
particular those of the trans-sialidase family. Here we discuss
how these previous studies and the new findings herein impact
our thoughts on the potential of prophylactic vaccination to
serve a productive role in the prevention of T. cruzi infection
and Chagas disease. |
Materia(s):
|
-Malaltia de Chagas -Vacunes -Chagas disease -Vaccines |
Derechos:
|
cc by-nc (c) Instituto Oswaldo Cruz, 2015
http://creativecommons.org/licenses/by-nc/3.0/es/ |
Tipo de documento:
|
Artículo Artículo - Versión aceptada |
Editor:
|
Instituto Oswaldo Cruz
|
Compartir:
|
|
Mostrar el registro completo del ítem