Per accedir als documents amb el text complet, si us plau, seguiu el següent enllaç: http://hdl.handle.net/2117/85186

Evaluation of multiple comparison correction procedures in drug assessment studies using LORETA maps
Alonso López, Joan Francesc; Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Ángel; Rojas Martínez, Mónica; Riba Serrano, Jordi; Barbanoj, Manuel José
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. BIOART - Anàlisi de Biosenyals per a la Rehabilitació i la Teràpia
The identification of the brain regions involved in the neuropharmacological action is a potential procedure for drug development. These regions are commonly determined by the voxels showing significant statistical differences after comparing placebo-induced effects with drug-elicited effects. LORETA is an electroencephalography (EEG) source imaging technique frequently used to identify brain structures affected by the drug. The aim of the present study was to evaluate different methods for the correction of multiple comparisons in the LORETA maps. These methods which have been commonly used in neuroimaging and also simulated studies have been applied on a real case of pharmaco-EEG study where the effects of increasing benzodiazepine doses on the central nervous system measured by LORETA were investigated. Data consisted of EEG recordings obtained from nine volunteers who received single oral doses of alprazolam 0.25, 0.5, and 1 mg, and placebo in a randomized crossover double-blind design. The identification of active regions was highly dependent on the selected multiple test correction procedure. The combined criteria approach known as cluster mass was useful to reveal that increasing drug doses led to higher intensity and spread of the pharmacologically induced changes in intracerebral current density.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
Brain mapping
Neuropharmacology
EEG tomography
LORETA
Multiple testing
Nonparametric permutation test
Cluster mass
Alprazolam
RESOLUTION ELECTROMAGNETIC TOMOGRAPHY
BRAIN ELECTRICAL-ACTIVITY
FALSE DISCOVERY RATE
DOUBLE-BLIND
ALZHEIMERS-DISEASE
PHARMACODYNAMICS
PERMUTATION
BUSPIRONE
TESTS
VOXEL
Cartografia cerebral
Neurofarmacologia
info:eu-repo/semantics/submittedVersion
Article
         

Mostra el registre complet del document

Documents relacionats

Altres documents del mateix autor/a

Alonso López, Joan Francesc; Mañanas Villanueva, Miguel Ángel; Romero Lafuente, Sergio; Rojas Martínez, Mónica; Riba Serrano, Jordi
Alonso López, Joan Francesc; Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Ángel; Riba Serrano, Jordi
Rojas Martínez, Mónica; Mañanas Villanueva, Miguel Ángel; Alonso López, Joan Francesc; Merletti, R.
Jordanic, Mislav; Rojas Martínez, Mónica; Mañanas Villanueva, Miguel Ángel; Alonso López, Joan Francesc
Mañanas Villanueva, Miguel Ángel; Rojas Martínez, Mónica; Alonso López, Joan Francesc