Title:
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Radiological findings in young children investigated for
tuberculosis in mozambique
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Author:
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García-Basteiro, Alberto L.; López-Varela, Elisa; Augusto, Orvalho; Gondo, Kizito; Muñoz, José; Sacarlal, Jahit; Marais, Ben; Alonso, Pedro; Ribo Aristizabal, Jose Luis
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Abstract:
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INTRODUCTION: Chest radiography remains a critical tool for
diagnosing intrathoracic tuberculosis (TB) in young children who
are unable to expectorate. We describe the radiological findings
in children under 3 years of age investigated for TB in the
district of Manhica, southern Mozambique, an area with a high
prevalence of TB and HIV. METHODS: Digital antero-posterior and
lateral projections were performed and reviewed by two
independent readers, using a standardized template. Readers
included a local pediatrician and a pediatric radiologist
blinded to all clinical information. International consensus
case definitions for intra-thoracic TB in children were applied.
RESULTS: A total of 766 children were evaluated of whom 43
(5.6%) had TB. The most frequent lesion found in TB cases was
air space consolidation (65.1%), followed by suggestive hilar
lymphadenopathy (17.1%) and pleural effusion (7.0%). Air space
consolidation was significantly more common in TB cases than in
non-TB cases (odds ratio 8.9; 95% CI: 1.6-50.5), as were hilar
lymphadenopathy (OR 17.2; 95% CI: 5.7-52.1). The only case with
miliary infiltrates and 3 with pleural effusions occurred in
HIV-infected children. CONCLUSION: Frequent air space
consolidation complicates radiological distinction between TB
and bacterial pneumonia in young children, underscoring the need
for epidemiological contextualization and consideration of all
relevant signs and symptoms. |
Subject(s):
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-Tuberculosi -Diagnòstic radiològic -Malalties dels infants -Moçambic -Radiografia -Tuberculosis -Radiography -Radioscopic diagnosis -Children's diseases -Mozambique |
Rights:
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cc by (c) García-Basteiro et al., 2015
http://creativecommons.org/licenses/by/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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Public Library of Science (PLoS)
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