dc.contributor.author |
Jennison, Charlie |
dc.contributor.author |
Arnott, Alicia |
dc.contributor.author |
Tessier, Natacha |
dc.contributor.author |
Tavul, Livingstone |
dc.contributor.author |
Koepfli, Cristian |
dc.contributor.author |
Felger, Ingrid |
dc.contributor.author |
Siba, Peter |
dc.contributor.author |
Reeder, John C. |
dc.contributor.author |
Bahlo, Melanie |
dc.contributor.author |
Mueller, Ivo |
dc.contributor.author |
Barry, Alyssa E. |
dc.date |
2016-01-14T13:09:59Z |
dc.date |
2016-01-14T13:09:59Z |
dc.date |
2015-04-15 |
dc.date |
2015-12-16T16:38:39Z |
dc.identifier.citation |
1935-2727 |
dc.identifier.uri |
http://hdl.handle.net/2445/68724 |
dc.format |
20 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Public Library of Science (PLoS) |
dc.relation |
Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pntd.0003634 |
dc.relation |
PLoS Neglected Tropical Diseases, 2015, vol. 9, num. 4, p. e0003634 |
dc.relation |
http://dx.doi.org/10.1371/journal.pntd.0003634 |
dc.rights |
cc by (c) Jennison et al., 2015 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es/ |
dc.subject |
Malària |
dc.subject |
Plasmodium falciparum |
dc.subject |
Genètica microbiana |
dc.subject |
Plasmodium vivax |
dc.subject |
Malaria |
dc.subject |
Plasmodium falciparum |
dc.subject |
Microbial genetics |
dc.subject |
Plasmodium vivax |
dc.title |
Plasmodium vivax Populations Are More Genetically Diverse and
Less Structured than Sympatric Plasmodium falciparum Populations |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
INTRODUCTION: The human malaria parasite, Plasmodium vivax, is
proving more difficult to control and eliminate than Plasmodium
falciparum in areas of co-transmission. Comparisons of the
genetic structure of sympatric parasite populations may provide
insight into the mechanisms underlying the resilience of P.
vivax and can help guide malaria control programs.
METHODOLOGY/PRINCIPLE FINDINGS: P. vivax isolates representing
the parasite populations of four areas on the north coast of
Papua New Guinea (PNG) were genotyped using microsatellite
markers and compared with previously published microsatellite
data from sympatric P. falciparum isolates. The genetic
diversity of P. vivax (He = 0.83-0.85) was higher than that of
P. falciparum (He = 0.64-0.77) in all four populations. Moderate
levels of genetic differentiation were found between P.
falciparum populations, even over relatively short distances
(less than 50 km), with 21-28% private alleles and clear
geospatial genetic clustering. Conversely, very low population
differentiation was found between P. vivax catchments, with less
than 5% private alleles and no genetic clustering observed. In
addition, the effective population size of P. vivax (30353;
13043-69142) was larger than that of P. falciparum (18871;
8109-42986). CONCLUSIONS/SIGNIFICANCE: Despite comparably high
prevalence, P. vivax had higher diversity and a panmictic
population structure compared to sympatric P. falciparum
populations, which were fragmented into subpopulations. The
results suggest that in comparison to P. falciparum, P. vivax
has had a long-term large effective population size, consistent
with more intense and stable transmission, and limited impact of
past control and elimination efforts. This underlines
suggestions that more intensive and sustained interventions will
be needed to control and eventually eliminate P. vivax. This
research clearly demonstrates how population genetic analyses
can reveal deeper insight into transmission patterns than
traditional surveillance methods. |