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Title:	Miniaturizable ion-selective arrays based on highly stable polymer membranes for biomedical applications
Author:	Mir Llorente, Mònica; Lugo, Roberto; Tahirbegi, Islam Bogachan; Samitier i Martí, Josep
Other authors:	Universitat de Barcelona
Abstract:	Poly(vinylchloride) (PVC) is the most common polymer matrix used in the fabrication of ion-selective electrodes (ISEs). However, the surfaces of PVC-based sensors have been reported to show membrane instability. In an attempt to overcome this limitation, here we developed two alternative methods for the preparation of highly stable and robust ion-selective sensors. These platforms are based on the selective electropolymerization of poly(3,4-ethylenedioxythiophene) (PEDOT), where the sulfur atoms contained in the polymer covalently interact with the gold electrode, also permitting controlled selective attachment on a miniaturized electrode in an array format. This platform sensor was improved with the crosslinking of the membrane compounds with poly(ethyleneglycol) diglycidyl ether (PEG), thus also increasing the biocompatibility of the sensor. The resulting ISE membranes showed faster signal stabilization of the sensor response compared with that of the PVC matrix and also better reproducibility and stability, thus making these platforms highly suitable candidates for the manufacture of robust implantable sensors. Keywords: ion-selective electrode (ISE) sensor, pH detection, ischemia, electrochemistry, implantable device, biomedicine, endoscope
Subject(s):	Elèctrodes selectius d'ions Isquèmia Cirurgia endoscòpica Electroquímica Ion selective electrodes Ischemia Endoscopic surgery Electrochemistry
Rights:	cc-by (c) Mir Llorente, Mònica et al., 2014 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article info:eu-repo/semantics/publishedVersion
Published by:	MDPI
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