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The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
Saurí Duran, Jaume; Millán, D.; Suñé i Negre, Josep M. (Josep Maria); Pérez Lozano, Pilar; Sarrate, R. (Rocío); Fábregas, A. (Anna); Carrillo Sánchez, Carolina; Miñarro Carmona, Montserrat; Ticó Grau, Josep R.; García Montoya, Encarna
The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.
Comprimits (Medicina)
Medicació oral
Excipients
Control de qualitat
Medicaments d'alliberament retardat
Tecnologia farmacèutica
Pólvores (Farmàcia)
Tablets (Medicine)
Oral medication
Excipients
Quality control
Delayed-action drugs
Pharmaceutical technology
Powders (Pharmacy)
(c) Elsevier B.V., 2014
Article
info:eu-repo/semantics/acceptedVersion
Elsevier B.V.
         

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