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Serotonergic psychedelics temporarily modify information transfer in humans
Alonso López, Joan Francesc; Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Ángel; Riba Serrano, Jordi
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. BIOART - Anàlisi de Biosenyals per a la Rehabilitació i la Teràpia
Background: Psychedelics induce intense modifications in the sensorium, the sense of "self," and the experience of reality. Despite advances in our understanding of the molecular and cellular level mechanisms of these drugs, knowledge of their actions on global brain dynamics is still incomplete. Recent imaging studies have found changes in functional coupling between frontal and parietal brain structures, suggesting a modification in information flow between brain regions during acute effects.; Methods: Here we assessed the psychedelic-induced changes in directionality of information flow during the acute effects of a psychedelic in humans. We measured modifications in connectivity of brain oscillations using transfer entropy, a nonlinear measure of directed functional connectivity based on information theory. Ten healthy male volunteers with prior experience with psychedelics participated in 2 experimental sessions. They received a placebo or a dose of ayahuasca, a psychedelic preparation containing the serotonergic 5-HT2A agonist N,N-dimethyltryptamine.; Results: The analysis showed significant changes in the coupling of brain oscillations between anterior and posterior recording sites. Transfer entropy analysis showed that frontal sources decreased their influence over central, parietal, and occipital sites. Conversely, sources in posterior locations increased their influence over signals measured at anterior locations. Exploratory correlations found that anterior-to-posterior transfer entropy decreases were correlated with the intensity of subjective effects, while the imbalance between anterior-to-posterior and posterior-to-anterior transfer entropy correlated with the degree of incapacitation experienced.; Conclusions: These results suggest that psychedelics induce a temporary disruption of neural hierarchies by reducing top-down control and increasing bottom-up information transfer in the human brain.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria electrònica::Electrònica biomèdica
Hallucinogenic drugs
Oscillatory brain dynamics
psychedelics
functional connectivity
transfer entropy
human
PSYCHOACTIVE BEVERAGE AYAHUASCA
POSITRON-EMISSION-TOMOGRAPHY
ALPHA-RHYTHM
PSYCHOMETRIC ASSESSMENT
RATING-SCALE
EEG
PSILOCYBIN
PSYCHOSIS
FMRI
Al·lucinògens
info:eu-repo/semantics/publishedVersion
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