Exploring Diallelic genetic markers: The Hardy Weinberg package

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To access the full text documents, please follow this link: http://hdl.handle.net/2117/76647

dc.contributor	Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.contributor	Universitat Politècnica de Catalunya. COSDA-UPC - COmpositional and Spatial Data Analysis
dc.contributor.author	Graffelman, Jan
dc.date	2015-03
dc.identifier.citation	Graffelman, J. Exploring Diallelic genetic markers: The Hardy Weinberg package. "Journal of statistical software", Març 2015, núm. 3, p. 1-23.
dc.identifier.citation	1548-7660
dc.identifier.uri	http://hdl.handle.net/2117/76647
dc.language.iso	cat
dc.relation	http://www.jstatsoft.org/
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Matemàtiques i estadística
dc.subject	Mathematical statistics
dc.subject	ternary plot
dc.subject	Q-Q plot
dc.subject	chi-square test
dc.subject	exact test
dc.subject	permutation test
dc.subject	power
dc.subject	log-ratio.
dc.subject	Estadística matemàtica -- Aplicacions
dc.title	Exploring Diallelic genetic markers: The Hardy Weinberg package
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package o ers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for testing equilibrium in the presence of missing data by using multiple imputation are provided. The package also supplies various graphical tools such as ternary plots with acceptance regions, log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets illustrate the use of the package.

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