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Title:	Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design
Author:	Castaño-Vinyals, Gemma; Aragonès Sanz, Núria; Pérez Gómez, Beatriz; Martín Sánchez, Vicente; Llorca Díaz, Javier; Moreno Aguado, Víctor; Altzibar, Jone M.; Ardanaz, Eva; Sanjosé Llongueras, Silvia de; Jiménez Moleón, José J.; Tardón, Adonina; Alguacil, Juan; Peiró Pérez, Rosana; Marcos Gragera, Rafael; Navarro Sánchez, Carmen; Pollán, Marina; Kogevinas, Manolis
Other authors:	Universitat de Barcelona
Abstract:	INTRODUCTION: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. METHODS: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. DISCUSSION: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.
Subject(s):	-Epidemiologia -Càncer colorectal -Càncer de pròstata -Càncer de mama -Epidemiology -Colorectal cancer -Prostate cancer -Breast cancer
Rights:	(c) Sociedad Española de Salud Pública y Administración Sanitaria (SESPAS), 2015
Document type:	Article Article - Accepted version
Published by:	Elsevier
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