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Visual interpretation of class C GPCR subtype overlapping from the nonlinear mapping of transformed primary sequences
Cárdenas Dominguez, Martha Ivón; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús
Universitat Politècnica de Catalunya. Departament de Ciències de la Computació; Universitat Politècnica de Catalunya. SOCO - Soft Computing
This brief paper addresses the problem of visually assessing the natural discriminability of the different subtypes that characterize class C G-Protein-Coupled Receptors, which are membrane proteins of interest in pharmacology, from diverse transformations of their primary amino acid sequences. Visualization, achieved using nonlinear dimensionality reduction techniques, is used as an exploratory tool to increase the interpretability of the data subtype structure. Combined with a quantitative estimation of subtype overlapping, this approach should be of help to experts in proteomics.
Peer Reviewed
Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
Amino acids
Biological membranes
Molecular biology
G protein coupled receptors
Membrane proteins
Nonlinear dimensionality reduction
Nonlinear mappings
Primary amino acid
Primary sequences
Quantitative estimation
Visual interpretation
Data visualization
Institute of Electrical and Electronics Engineers (IEEE)

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