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Cardiac contraction induces discordant alternans and localized block
Radszuweit, M.; Álvarez Lacalle, Enrique; Bär, Markus; Echebarría Domínguez, Blas
Universitat Politècnica de Catalunya. Departament de Física Aplicada; Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
In this paper we use a simplified model of cardiac excitation-contraction coupling to study the effect of tissue deformation on the dynamics of alternans, i.e., alternations in the duration of the cardiac action potential, that occur at fast pacing rates and are known to be proarrhythmic. We show that small stretch-activated currents can produce large effects and cause a transition from in-phase to off-phase alternations (i.e., from concordant to discordant alternans) and to conduction blocks. We demonstrate numerically and analytically that this effect is the result of a generic change in the slope of the conduction velocity restitution curve due to electromechanical coupling. Thus, excitation-contraction coupling can potentially play a relevant role in the transition to reentry and fibrillation.
Peer Reviewed
Àrees temàtiques de la UPC::Ciències de la salut
Heart--Electric properties
Heart--Mechanical properties
STRETCH-INDUCED CHANGES
T-WAVE
MECHANOELECTRIC FEEDBACK
ELECTRICAL ALTERNANS
EXCITABLE MEDIA
SPIRAL WAVES
MECHANISMS
TISSUE
VULNERABILITY
FIBRILLATION
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/publishedVersion
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