The aim of this research is the design, implementation and evaluation of a Software Reference Architecture for WfLMS (Workflow Learning Management Systems) with Mobile, Cloud and Collaborative functionalities. The Reference Architecture was the result of applying the Workflow Management System Reference Model in conjunction with Mobile, Cloud and Collaborative Architectural pattern solutions. The Design Science Research methodology was applied in this research as the principal goal of the research is the same as in the methodology, the creation of artifacts for a practical purpose. The implementation of the Reference Architecture resulted in a mobile WfLMS for the iOS platform. A Delphi Study with a group of 12 experts was carried out in order to evaluate if the Mobile, Cloud and Collaborative architectural pattern solutions applied in the Reference Architecture enhanced the functionalities of a WfLMS. 14 factors were identified in the pattern solutions that were implemented, the experts ranked each one of the factors with a 5 point Likert scale in a 3 round questionnaire. 12 of the factors achieved more than 75% of agreement with a strong level of group consensus.