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Title:	Molecular Na-channel excitability from statistical physics
Author:	Ramírez de la Piscina Millán, Laureano; Sancho Herrero, José María
Other authors:	Universitat Politècnica de Catalunya. Departament de Física Aplicada; Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
Abstract:	The excitable properties of the neural cell membrane is the driving mechanism of the neural pulses. Coordinated ionic fluxes across Na and K channels are the devices responsible of this function. Here we present a simple microscopic physical scenario which accounts for this phenomenology. The main elements are ions and channel doors that obey the standard formulation of statistical physics (overdamped Langevin equations) with appropriate nonlinear interacting potentials. From these equations we obtain the ionic flux and the dynamics of the membrane potential. We show that the excitable properties of the membrane are present in a single and simple Na channel. From this framework, additional microscopic information can be obtained, such as statistics of single-channels dynamics or the energetics of action potential events.
Abstract:	Peer Reviewed
Subject(s):	-Àrees temàtiques de la UPC::Física::Termodinàmica::Física estadística -Stochastic analysis -Ion channels -Molecular channels Action potential Langevin equations -Anàlisi estocàstica -Canals iònics
Rights:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Document type:	Article - Submitted version Article
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