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Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons
Reverter Cubarsí, Ferran; Prodromakis, Themis; Liu, Yan; Georgiou, Pantelis; Nikolic, Konstantin; Constandinou, Tim
Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica; Universitat Politècnica de Catalunya. e-CAT - Transductors i Circuits Electrònics
This paper identifies and addresses key design considerations and trade-offs in the implementation of a CMOS high-resolution microheater array for Lab-on-Chip (LOC) applications. Specifically, this is investigated in the context of facilitating the in vitro thermal stimulation of single neurons. The paper analyses the electro-thermal response (by means of COMSOL simulations) and reliability issues (such as melting and electromigration) of different microheater designs. The analysis shows that a small-area heater is more efficient in terms of power, but it has more reliability problems essentially due to electromigration effects. For the proposed heater designs, the expected lifetime is a few days (in continuous operation) in the worst scenario, which is still generally acceptable for LOC applications.
Peer Reviewed
Àrees temàtiques de la UPC::Física::Electromagnetisme
Àrees temàtiques de la UPC::Enginyeria electrònica::Electrònica de potència
Electronic circuits
thermal stimulation
Circuits electronics
Institute of Electrical and Electronics Engineers (IEEE)

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