Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/64890

Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century
Franco Fernández, Rafael; Navarro Brugal, Gemma; Martínez-Pinilla, E.; Moreno Guillén, Estefanía
Universitat de Barcelona
The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer's disease patients. Expression in different tissues and the degree of sequence identity among mammals indicate an essential and non-tissue specific physiological function. APP is anchored to the membrane and displays a single C-terminal intracellular domain and a longer N-terminal extracellular domain. The basic biochemical properties and the scattered data on research, not related to production of beta-amyloid peptide, suggest that the protein and the molecules resulting from APP proteolytic cleavage may act as adhesion factors, enzymes, hormones/neurotransmitters and/or protease inhibitors. APP deserves to be known for its quite notable properties and its physiological role(s).
Malaltia d'Alzheimer
Expressió gènica
Proteïnes de membrana
Alzheimer's disease
Gene expression
Membrane proteins
(c) Franco Fernández, Rafael et al., 2014
Artículo
info:eu-repo/semantics/publishedVersion
Annex Publishers
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

González, Sergio; Moreno Delgado, David; Moreno Guillén, Estefanía; Pérez Capote, Kamil; Franco Fernández, Rafael; Mallol Montero, Josefa; Cortés Tejedor, Antonio; Casadó, Vicent; Lluís i Biset, Carme; Ortiz, Jordi; Ferré, Sergi; Canela Campos, Enric I.; McCormick, Peter J.
Viñals, Xavier.; Moreno Guillén, Estefanía; Lanfumey, Laurence; Cordomí, Arnau; Pastor Bosch, Antonio; De la Torre Fornell, Rafael; Navarro, Gemma; Gasperini, Paola .; Howell, Lesley A.; Pardo, Leonardo; Lluís i Biset, Carme; Canela Campos, Enric I; McCormick, Peter J.; Maldonado, Rafael, 1961-; Robledo, Patricia.
Rodríguez García, M.; Climent, N.; Oliva, H.; Casanova, V.; Franco Fernández, Rafael; Leon, A.; Gatell, José M.; García, F.; Gallart, T.
Rodríguez García, M.; Climent, N.; Oliva, H.; Casanova, V.; Franco Fernández, Rafael; Leon, A.; Gatell, José M.; García, F.; Gallart, T.
Orru, M.; Bakešová, Jana; Brugarolas, M.; Quiroz, C.; Beaumont, V.; Goldberg, S. R.; Lluís i Biset, Carme; Cortés Tejedor, Antonio; Franco Fernández, Rafael; Casadó, Vicent; Canela Campos, Enric I.; Ferré, S.