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Study of the Microfluidic Crystallization of a Pharmaceutical Compound
Casadevall Gras, Noemí
Scheid, Benoit
The purpose of this thesis is to study the crystallization in a microfluidic device of an active pharmaceutical ingredient which is (2S)-2-[(4R)-2-oxo- 4-propylpyrrolidin-1-yl] butanamide, with product name Brivaracetam. This molecule is manufactured by the Belgian pharmaceutical industry UCB, and a better understanding of its crystallization in the microscopic scale, and especially its polymorphism, would lead to new possibilities in order to develop a future industrial continuous crystallizer based in the microfluidic technology. For this purpose, several experiments have been run, both in the macroscopic scale and using the microfluidics technology. The solubility curve for the system was determined, and also a cluster formation was analysed using volumes around 10ml of solution. Several crystallizations were done also with solutions of this volume to first understand the polymorphism that the solute presents. For the micro-scale crystallizations, the microfluidic device used was a system composed by Teflon capillary tubes and pieces made of PEEK. This method consists in the generation and storage of droplets of the solution to crystallize inside the microfluidic channels, and observation of its crystallization. At the end, the determination of the optimum working conditions for a microfluidic crystallization of the desired morph was not achieved. However, it has been proved it is possible to obtain crystallization of the solute in the desired morph inside the droplets in a microfluidic device, and that it is also possible to obtain one and only one crystal per droplet.
Àrees temàtiques de la UPC::Enginyeria química::Química física::Cristal·lografia
Microfluidic devices
microfluidic device
solubility curve
Dispositius microfluidics
Universitat Politècnica de Catalunya;
Université Libre Bruxelles

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