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The Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
Casas, R.; Sacanella Meseguer, Emilio; Urpí Sardà, Mireia; Chiva Blanch, Gemma; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Covas Planells, María Isabel; Lamuela Raventós, Rosa Ma.; Salas Salvadó, Jordi; Fiol Sala, Miguel; Arós, Fernando; Estruch Riba, Ramon
Universitat de Barcelona
Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. Aim: To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarkers related to atherosclerosis and plaque vulnerability in a subcohort of the PREDIMED (Prevencion con Dieta Mediterranea) study. Methods: A total of 164 participants at high risk for cardiovascular disease were randomized into three diet groups: MD supplemented with 50 mL/d of extra virgin olive oil (MD+EVOO) or 30 g/d of nuts (MD+Nuts) and a low-fat diet. Changes in classical cardiovascular risk factors, inflammatory biomarkers of atherosclerosis and plaque vulnerability were measured after 12 months of intervention. Results: Compared to participants in the low-fat diet group, those receiving MD+EVOO and MD+Nuts showed a higher decrease in systolic (6 mmHg)and diastolic (3 mmHg) blood pressure (P = 0.02; both), as well as a reduction of 10% and 8% in LDL-cholesterol (P = 0.04), respectively. Patients in the MD+Nuts group showed a significant reduction of 34% in CD40 expression on monocyte surface compared to low-fat diet patients (P = 0.03). In addition, inflammatory biomarkers related to plaque instability such as C-reactive protein and interleukin-6 were reduced by 45% and 35% and 95% and 90% in the MD+EVOO and MD+Nuts groups, respectively (P<0.05; all) compared to the low-fat diet group. Likewise, sICAM and Pselectin were also reduced by 50% and 27%, respectively in the MD+ EVOO group (P = 0.04) and P-selectin by 19% in MD+Nuts group (P = 0.04) compared to the low-fat diet group. Conclusions: Adherence to the MD is associated with an increase in serum markers of atheroma plaque stability which may explain, at least in part, the protective role of MD against ischemic heart disease.
Infermeria cardiovascular
Dieta
Olis vegetals
Cardiovascular disease nursing
Diet
Vegetable oils
cc-by (c) Casas, R. et al., 2014
http://creativecommons.org/licenses/by/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
Public Library of Science (PLoS)
         

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Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, V.; Lapetra, J.; García Valdueza, Marta; Arós, Fernando; Sáez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.
Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, V.; Lapetra, J.; García Valdueza, Marta; Arós, Fernando; Saez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.
Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, V.; Lapetra, J.; García Valdueza, Marta; Arós, Fernando; Saez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.
Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, V.; Lapetra, J.; García Valdueza, Marta; Arós, Fernando; Saez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.
Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, Valentina; Lapetra, José; García Valdueza, Marta; Arós, Fernando; Sáez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.