Title:
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Physiological conditioning by electric field stimulation promotes cardiomyogenic gene expression in human cardiomyocyte progenitor cells
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Author:
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Llucía Valldeperas, Aida; Sánchez Terrones, Benjamin; Soler Botija, Carolina; Gálvez Montón, Carolina; Roura, Santiago; Prat Vidal, Cristina; Perea Gil, Isaac; Rosell Ferrer, Francisco Javier; Bragós Bardia, Ramon; Bayés-Genís, Antoni
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica; Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica |
Abstract:
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The optimal cell lineage for cardiac-regeneration approaches remains mysterious. Additionally, electrical stimulation promotes cardiomyogenic differentiation of stimulated cells. Therefore, we hypothesized that electrical conditioning of cardiomyocyte progenitor cells (CMPCs) might enrich their cardiovascular potential. CMPCs were isolated from human adult atrial appendages, characterized, and electrically stimulated for 7 and 14 days. Electrical stimulation modulated CMPCs gene and protein expression, increasing all cardiac markers. GATA-binding protein 4 (GATA4) early transcription factor was significantly overexpressed (P = 0.008), but also its coactivator myocyte enhancer factor 2A (MEF2A) was upregulated (P = 0.073) under electrical stimulation. Moreover, important structural proteins and calcium handling-related genes were enhanced. The cardioregeneration capability of CMPCs is improved by electrical field stimulation. Consequently, short-term electrical stimulation should be a valid biophysical approach to modify cardiac progenitor cells toward a cardiogenic phenotype, and can be incorporated into transdifferentiation protocols. Electrostimulated CMPCs may be best-equipped cells for myocardial integration after implantation. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Ciències de la salut::Medicina -Àrees temàtiques de la UPC::Física::Electromagnetisme::Ones electromagnètiques -Stem cells -Electric fields -In-vitro -Cèl·lules mare -Camps elèctrics |
Rights:
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Reconeixement 3.0 Espanya
http://creativecommons.org/licenses/by/3.0/es/ |
Document type:
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Article - Published version Article |
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