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Effect of structure, topography and chemistry on fibroblast adhesion and morphology
Mateos Timoneda, Miguel Ángel; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Institut de Bioenginyeria de Catalunya; Universitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
Surface biofunctionalisation of many biodegradable polymers is one of the used strategies to improve the biological activity of such materials. In this work, the introduction of collagen type I over the surface of a biodegradable polymer (poly lactic acid) processed in the forms of films and fibers leads to an enhancing of the cellular adhesion of human dermal fibroblast when compared to unmodified polymer and biomolecule-physisorbed polymer surface. The change of topography of the material does not affect the cellular adhesion but results in a higher proliferation of the fibroblast cultured over the fibers. Moreover, the difference of topography governs the cellular morphology, i.e. cells adopt a more stretched conformation where cultured over the films while a more elongated with lower area morphology are obtained for the cells grown over the fibers. This study is relevant for designing and modifying different biodegradable polymers for their use as scaffolds for different applications in the field of Tissue Engineering and Regenerative Medicine.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria dels materials
Tissue engineering
Regenerative medicine
Biomedical materials
Engineering controlled terms: Adhesion
Bioactivity
Biodegradable polymers
Cell culture
Fibroblasts
Lactic acid
Polymer films
Scaffolds (biology) Biofunctionalisation
Cellular adhesion
Cellular morphology
Fibroblast adhesion
Human dermal fibroblasts
Poly lactic acid
Polymer surfaces
Regenerative medicine
Enginyeria de teixits
Medicina regenerativa
Biomaterials
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/publishedVersion
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