Nanoparticles of esterified polymalic acid for controlled anticancer drug release

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dc.contributor	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor	Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics
dc.contributor.author	Lanz Landazuri, Alberto
dc.contributor.author	Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon
dc.contributor.author	Portilla Arias, Jose Antonio
dc.contributor.author	García Álvarez, Montserrat
dc.contributor.author	Holler, Eggehard
dc.contributor.author	Ljubimova, Julia
dc.contributor.author	Muñoz Guerra, Sebastián
dc.date	2014-09-01
dc.identifier.citation	Lanz, A. [et al.]. Nanoparticles of esterified polymalic acid for controlled anticancer drug release. "Macromolecular bioscience", 01 Setembre 2014, vol. 14, núm. 9, p. 1325-1336.
dc.identifier.citation	1616-5187
dc.identifier.citation	10.1002/mabi.201400124
dc.identifier.uri	http://hdl.handle.net/2117/24073
dc.language.iso	eng
dc.relation	http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400124/abstract
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria química
dc.subject	Nanoparticles--Therapeutic use
dc.subject	Antineoplastic agents
dc.subject	biodegradable drug delivery systems
dc.subject	poly(malic acid)
dc.subject	poly(malic acid) nanoparticles
dc.subject	Nanopartícules -- Ús terapèutic
dc.subject	Medicaments antineoplàstics
dc.title	Nanoparticles of esterified polymalic acid for controlled anticancer drug release
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Esterification of microbial poly(malic acid) is performed with either ethanol or 1-butanol to obtain polymalate conjugates capable to form nanoparticles (100–350 nm). Degradation under physiological conditions takes place with release of malic acid and the corresponding alcohol as unique degradation products. The anticancer drugs Temozolomide and Doxorubicin are encapsulated in nanoparticles with efficiency of 17 and 37%, respectively. In vitro drug release assays show that Temozolomide is almost completely discharged in a few hours whereas Doxorubicin is steadily released along several days. Drug-loaded nano-particles show remarkable effectiveness against cancer cells. Partially ethylated poly(malic acid) nano-particles are those showing the highest cellular uptake.
dc.description.abstract	Peer Reviewed

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