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Mitochondrial fatty acid oxidation in obesity
Serra i Cucurull, Dolors; Mera Nanín, Paula; Malandrino, Maria Ida; Mir, Joan Francesc; Herrero Rodríguez, Laura
Universitat de Barcelona
Significance: Current lifestyles with high-energy diets and little exercise are triggering an alarming growth in obesity. Excess of adiposity is leading to severe increases in associated pathologies, such as insulin resistance, type 2 diabetes, atherosclerosis, cancer, arthritis, asthma, and hypertension. This, together with the lack of efficient obesity drugs, is the driving force behind much research. Recent Advances: Traditional anti-obesity strategies focused on reducing food intake and increasing physical activity. However, recent results suggest that enhancing cellular energy expenditure may be an attractive alternative therapy. Critical Issues: This review evaluates recent discoveries regarding mitochondrial fatty acid oxidation (FAO) and its potential as a therapy for obesity. We focus on the still controversial beneficial effects of increased FAO in liver and muscle, recent studies on how to potentiate adipose tissue energy expenditure, and the different hypotheses involving FAO and the reactive oxygen species production in the hypothalamic control of food intake. Future Directions: The present review aims to provide an overview of novel anti-obesity strategies that target mitochondrial FAO and that will definitively be of high interest in the future research to fight against obesity-related disorders.
Àcids grassos
Terapèutica
Teixit adipós
Quimioteràpia
Reacció d'oxidació-reducció
Metabolisme dels lípids
Obesitat
Mitocondris
Fatty acids
Therapeutics
Adipose tissues
Chemotherapy
Oxidation-reduction reaction
Lipid metabolism
Obesity
Mitochondria
(c) Mary Ann Liebert, Inc., 2013
Article
info:eu-repo/semantics/publishedVersion
Mary Ann Liebert, Inc.
         

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