dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Egaña Gorroño, Lander |
dc.contributor.author |
Martínez Chamorro, Esteban José |
dc.contributor.author |
Escribà, Tuixent |
dc.contributor.author |
Calvo, Marta |
dc.contributor.author |
Gatell, José M. |
dc.contributor.author |
Arnedo, Mireia |
dc.date |
2014-07-28T12:03:36Z |
dc.date |
2014-07-28T12:03:36Z |
dc.date |
2012-12-06 |
dc.date |
2014-07-28T12:03:36Z |
dc.identifier.citation |
627367 |
dc.identifier.uri |
http://hdl.handle.net/2445/56372 |
dc.format |
4 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Frontiers Media |
dc.relation |
Reproducció del document publicat a: http://dx.doi.org/10.3389/fimmu.2012.00367 |
dc.relation |
Frontiers in Immunology, 2012, vol. 3, p. 367 |
dc.relation |
http://dx.doi.org/10.3389/fimmu.2012.00367 |
dc.rights |
cc-by (c) Egana-Gorrono, L. et al., 2012 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es |
dc.subject |
Malalties del cor |
dc.subject |
Lipoproteïnes |
dc.subject |
Infeccions per VIH |
dc.subject |
Sida |
dc.subject |
Heart diseases |
dc.subject |
Lipoproteins |
dc.subject |
HIV infections |
dc.subject |
AIDS (Disease) |
dc.title |
Association study of lipoprotein(a) genetic markers, traditional risk factors, and coronary heart disease in HIV-1-infected patients. |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Objectives: General population studies have shown associations between copy number variation (CNV) of the LPA gene Kringle-IV type-2 (KIV-2) coding region, single-nucleotide polymorphism (SNP) rs6415084 in LPA and coronary heart disease (CHD). Because risk factors for HIV-infected patients may differ from the general population, we aimed to assess whether these potential associations also occur in HIV-infected patients. Methods: A unicenter, retrospective, case-control (1:3) study. Eighteen HIV-patients with confirmed diagnosis of acute myocardial infarction (AMI) were adjusted for age, gender, and time since HIV diagnosis to 54 HIV-patients without CHD. After gDNA extraction from frozen blood, both CNV and SNP genotyping were performed using real-time quantitative PCR. All genetic and non-genetic variables for AMI were assessed in a logistic regression analysis. Results: Our results did not confirm any association in terms of lipoprotein(a) LPA structural genetic variants when comparing KIV-2 CNV (p = 0.67) and SNP genotypes (p = 0.44) between AMI cases and controls. However, traditional risk factors such as diabetes mellitus, hypertension, and CD4(+) T cell count showed association (p < 0.05) with CHD. Conclusion: Although significant associations of AMI with diabetes, hypertension and CD4(+) T cell count in HIV-patients were found, this study could not confirm the feasibility neither of KIV-2 CNV nor rs6415084 in LPA as genetic markers of CHD in HIV-infected patients.Highlights:● Individuals with HIV infection are at higher risk of coronary heart disease (CHD) than the non-infected population.● Our results showed no evidence of LPA structural genetic variants associated with CHD in HIV-1-infected patients.● Associations were found between diabetes mellitus, arterial hypertension, CD4(+) T cell count, and CHD.● The clinical usefulness of these biomarkers to predict CHD in HIV-1-infected population remains unproven.● Further studies are needed to assess the contribution of common genetic variations to CHD in HIV-infected individuals. |