Poly(beta,L-malic acid)Doxorubicin ionic complex: A pH-dependent delivery system.

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To access the full text documents, please follow this link: http://hdl.handle.net/2117/23603

dc.contributor	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor	Universitat Politècnica de Catalunya. POL - Polímers
dc.contributor.author	Lanz Landazuri, Alberto
dc.contributor.author	Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon
dc.contributor.author	García Álvarez, Montserrat
dc.contributor.author	Muñoz Guerra, Sebastián
dc.date	2014-07-24T11:28:54Z
dc.date	2014-08-01
dc.date	2014-08-01
dc.date	10000-01-01
dc.date.accessioned	2014-07-26T22:12:10Z
dc.date.available	2014-07-26T22:12:10Z
dc.date.issued	2014-07-26T22:12:10Z
dc.identifier.citation	Lanz, A. [et al.]. Poly(beta,L-malic acid)Doxorubicin ionic complex: A pH-dependent delivery system.. "Reactive and functional polymers", 01 Agost 2014, vol. 81, p. 45-53.
dc.identifier.citation	1381-5148
dc.identifier.citation	10.1016/j.reactfunctpolym.2014.04.005
dc.identifier.uri	http://hdl.handle.net/2117/23603
dc.format	9 p.
dc.language.iso	eng
dc.relation	http://www.sciencedirect.com/science/article/pii/S1381514814000959#
dc.rights	Restricted access - publisher's policy
dc.subject	Àrees temàtiques de la UPC::Enginyeria química
dc.subject	Biopolymers
dc.subject	Drug development
dc.subject	Poly(malic acid)
dc.subject	Ionic complexes
dc.subject	Doxorubicin complex
dc.subject	pH-dependent
dc.subject	Drug-delivery particle
dc.subject	Biopolímers
dc.subject	Medicaments -- Desenvolupament
dc.title	Poly(beta,L-malic acid)Doxorubicin ionic complex: A pH-dependent delivery system.
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Poly(ß,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength
dc.description.abstract	Peer Reviewed
dc.description.abstract	Postprint (published version)

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