To access the full text documents, please follow this link: http://hdl.handle.net/2117/23603

Poly(beta,L-malic acid)Doxorubicin ionic complex: A pH-dependent delivery system.
Lanz Landazuri, Alberto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; García Álvarez, Montserrat; Muñoz Guerra, Sebastián
Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. POL - Polímers
Poly(ß,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength
Peer Reviewed
Postprint (published version)
2014-07-26
Àrees temàtiques de la UPC::Enginyeria química
Biopolymers
Drug development
Poly(malic acid)
Ionic complexes
Doxorubicin complex
pH-dependent
Drug-delivery particle
Biopolímers
Medicaments -- Desenvolupament
Restricted access - publisher's policy
Article
         

Show full item record

Related documents

Other documents of the same author

Lanz Landazuri, Alberto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Holler, Eggehard; Ljubimova, Julia; Muñoz Guerra, Sebastián
Lanz Landazuri, Alberto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; García Álvarez, Montserrat; Muñoz Guerra, Sebastián
Lanz, Alberto; García Álvarez, Montserrat; Portilla Arias, Jose Antonio; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Patil, Rameshwar; Holler, Eggehard; Ljubimova, Julia Y.; Muñoz Guerra, Sebastián
Lanz, Alberto; García Álvarez, Montserrat; Portilla Arias, Jose Antonio; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Holler, Eggehard; Ljubimova, Julia Y.; Muñoz Guerra, Sebastián
Giammanco, Giuseppe; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Alla Bedahnane, Abdelilah; Muñoz Guerra, Sebastián
 

Coordination

 

Supporters