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Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds
Serra, Tiziano; Ortiz Hernández, Mónica; Engel López, Elisabeth; Planell Estany, Josep Anton; Navarro Toro, Melba Eugenia
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Institut de Bioenginyeria de Catalunya; Universitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
Achieving high quality 3D-printed structures requires establishing the right printing conditions. Finding processing conditions that satisfy both the fabrication process and the final required scaffold properties is crucial. This work stresses the importance of studying the outcome of the plasticizing effect of PEG on PLA-based blends used for the fabrication of 3D-direct-printed scaffolds for tissue engineering applications. For this, PLA/PEG blends with 5, 10 and 20% (w/w) of PEG and PLA/PEG/bioactive CaP glass composites were processed in the form of 3D rapid prototyping scaffolds. Surface analysis and differential scanning calorimetry revealed a rearrangement of polymer chains and a topography, wettability and elastic modulus increase of the studied surfaces as PEG was incorporated. Moreover, addition of 10 and 20% PEG led to non-uniform 3D structures with lower mechanical properties. In vitro degradation studies showed that the inclusion of PEG significantly accelerated the degradation rate of the material. Results indicated that the presence of PEG not only improves PLA processing but also leads to relevant surface, geometrical and structural changes including modulation of the degradation rate of PLA-based 3D printed scaffolds. (C) 2014 Elsevier B.V. All rights reserved.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria dels materials
Tissue engineering
Tissue scaffolds
Rapid prototyping
Polylactic acid
Surface characterization
Enginyeria de teixits
Teixits -- Bastides
Attribution-NonCommercial-NoDerivs 3.0 Spain

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