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Isolation, structural assignment and total synthesis of Barmumycin
Lorente, Adriana; Pla Queral, Daniel; Cañedo, Librada M.; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes
Universitat de Barcelona
Barmumycin was isolated from an extract of the marine actinomycete Streptomyces sp. BOSC-022A and found to be cytotoxic against various human tumor cell lines. Based on preliminary one- and two-dimensional 1H- and 13C-NMR spectra, the natural compound was initially assigned the structure of macrolactone-type compound 1, which was later prepared by two different routes. However, major spectroscopic differences between isolated barmumycin and 1 led to revision of the proposed structure as E-16. Based on synthesis of this new compound, and subsequent spectroscopic comparison of it to an authentic sample of barmumycin, the structure of the natural compound was indeed confirmed as that of E-16.
Medicaments antineoplàstics
Productes naturals marins
Lactones
Imidazoles
Antineoplastic agents
Marine natural products
Lactones
Imidazoles
(c) American Chemical Society , 2010
Artículo
info:eu-repo/semantics/acceptedVersion
American Chemical Society
         

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