Utilizad este identificador para citar o enlazar este documento: http://hdl.handle.net/2072/233418

Convergent Approaches for the Synthesis of the Anti-tumoral Peptide, Kahalalide F. Study of Orthogonal Protecting Groups
Gracia, C.; Isidro Llobet, Albert; Cruz, L. J.; Acosta, Gerardo A.; Álvarez Domingo, Mercedes; Cuevas, C.; Giralt Lledó, Ernest; Albericio Palomera, Fernando
Kahalalide compounds are peptides that are isolated from a Hawaiian herbivorous marine species of mollusc, Elysia rufescens, and its diet, the green alga Bryopsis sp. Kahalalide F and its synthetic analogues are the most promising compounds of the Kahalalide family because they show anti-tumoral activity. Linear solid-phase syntheses of Kahalalide F have been reported. Here we describe several new improved synthetic routes based on convergent approaches with distinct orthogonal protection schemes for the preparation of Kahaladide analogues. These strategies allow a better control and characterization of the intermediates because more reactions are performed in solution. Five derivatives of Kahalalide F were synthesized using several convergent approaches.
18-06-2014
Pèptids
Medicaments antineoplàstics
Productes marins naturals
Peptides
Antineoplastic agents
Marine natural products
(c) American Chemical Society , 2006
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info:eu-repo/semantics/acceptedVersion
American Chemical Society
         

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