Título:
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Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine
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Autor/a:
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Just Baringo, Xavier; Bruno, Paolo; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes
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Otros autores:
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Universitat de Barcelona |
Abstract:
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(S)-2-(4-Bromo-2,4"-bithiazole)-1-(tert-butoxycarbonyl)pyrrolidine ((S)-1) was obtained as a single enantiomer and in high yield by means of a two-step modified Hantzsch thiazole synthesis reaction when bromoketone 3 and thioamide (S)-4 were used. Further conversion of (S)-1 into trimethyltin derivative (S)-2 broadens the scope for further cross-coupling reactions. |
Materia(s):
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-Productes naturals -Antibiòtics -Síntesi de pèptids -Compostos heterocíclics -Enantiòmers -Natural products -Antibiotics -Peptide synthesis -Heterocyclic compounds -Enantiomers |
Derechos:
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(c) Elsevier Ltd, 2011
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Elsevier Ltd
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Compartir:
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