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Evidence of an efflux pump in Serratia marcescens
Berlanga Herranz, Mercedes; Vázquez, J. L.; Borrell Hernández, Jordi; Montero Barrientos, Ma. Teresa; Viñas, Miquel
Universitat de Barcelona
Spontaneous mutants resistant to fluoroquinolones were obtained by exposing Serratia marcescens NIMA (wild-type strain) to increasing concentrations of ciprofloxacin both in liquid and on solid media. Frequencies of mutation ranged from 10-7 to 10-9. Active expulsion of antibiotic was explored as a possible mechanism of resistance in mutants as well as changes in topoisomerase target genes. The role of extrusion mechanisms in determining the emergence of multidrug-resistant bacteria was also examined. Mutants resistant to high concentrations of fluoroquinolones had a single mutation in their gyrA QRDR sequences, whereas the moderate resistance in the rest of mutants was due to extrusion of the drug
Resistència als medicaments
Antibiòtics
Serratia marcescens
Medicaments antibacterians
Drug resistance
Antibiotics
Serratia marcescens
(c) Mary Ann Liebert, Inc., 2000
Artículo
info:eu-repo/semantics/publishedVersion
Mary Ann Liebert, Inc.
         

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